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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69358
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sost
Name: sclerostin
Acc ID: CHEBI:28741
Term: sodium fluoride
Definition: A metal fluoride salt with a Na(+) counterion.
Chemical ID: MESH:D012969
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sostdecreases expressionEXP 6480464CTDSodium Fluoride results in decreased expression of SOST mRNAPMID:29447955
Sostmultiple interactionsEXP 6480464CTDPTH protein inhibits the reaction [Sodium Fluoride results in decreased expression of SOST mRNA]PMID:29447955
Sostdecreases expressionISOSost (Mus musculus)6480464CTDSodium Fluoride results in decreased expression of SOST mRNA; Sodium Fluoride results in decreased expression of SOST proteinPMID:29447955 PMID:32156525
Sostmultiple interactionsISOSost (Mus musculus)6480464CTD[PTH protein results in increased susceptibility to Sodium Fluoride] which results in increased expression of SOST mRNA; PTH protein affects the reaction [Sodium Fluoride results in decreased expression of SOST protein]; PTH protein inhibits the reaction [Sodium Fluoride results in decreased expression of SOST protein]; Sodium Fluoride affects the reaction [PTH protein results in decreased expression of SOST mRNA]; Sodium Fluoride promotes the reaction [PTH protein results in decreased expression of SOST mRNA]PMID:29447955 PMID:32156525
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