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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10916
Species: Mus musculus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:28738
Term: 2,6-dimethylaniline
Definition: A primary arylamine that is aniline in which the hydrogens at the 2- and 6-positions are replaced by methyl groups. It is used in the production of some anasthetics and other chemicals. It is a drug metabolite of lidocaine (local anasthetic).
Chemical ID: MESH:C007766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpomultiple interactionsISOMPO (Homo sapiens)6480464CTD[[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidinePMID:20199096
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