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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737517
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:28714
Term: S-butyl-DL-homocysteine (S,R)-sulfoximine
Definition: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
Chemical ID: MESH:D019328
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT3increases activityISOStat3 (Rattus norvegicus)6480464CTDButhionine Sulfoximine results in increased activity of STAT3 proteinPMID:11841787
STAT3increases expressionISOStat3 (Rattus norvegicus)6480464CTDButhionine Sulfoximine results in increased expression of STAT3 mRNAPMID:11841787
STAT3multiple interactionsISOStat3 (Mus musculus)6480464CTD[Troglitazone co-treated with Buthionine Sulfoximine] results in increased phosphorylation of STAT3 proteinPMID:31294483
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