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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734356
Species: Homo sapiens
RGD Object: Gene
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:28714
Term: S-butyl-DL-homocysteine (S,R)-sulfoximine
Definition: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
Chemical ID: MESH:D019328
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JUNdecreases activityEXP 6480464CTDButhionine Sulfoximine results in decreased activity of JUN proteinPMID:11849044
JUNmultiple interactionsEXP 6480464CTDButhionine Sulfoximine inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]PMID:11341981
JUNincreases expressionISOJun (Mus musculus)6480464CTDButhionine Sulfoximine results in increased expression of JUN mRNAPMID:18449455 PMID:21825963
JUNincreases expressionISOJun (Rattus norvegicus)6480464CTDButhionine Sulfoximine results in increased expression of JUN mRNAPMID:11841787 PMID:7626009
JUNmultiple interactionsISOJun (Mus musculus)6480464CTDButhionine Sulfoximine inhibits the reaction [Sodium Selenite results in increased expression of JUN mRNA]; Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Buthionine Sulfoximine promotes the reaction [Trioxsalen analog results in decreased activity of JUN protein]; Glucosamine analog inhibits the reaction [Buthionine Sulfoximine results in increased expression of JUN mRNA]PMID:15520183 PMID:16259964 PMID:18449455 PMID:21825963
JUNmultiple interactionsISOJun (Rattus norvegicus)6480464CTDButhionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]PMID:7743507
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