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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736610
Species: Mus musculus
RGD Object: Gene
Symbol: Akr1b1
Name: aldo-keto reductase family 1 member B
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1b1decreases expressionISOAkr1b1 (Rattus norvegicus)6480464CTDCopper deficiency results in decreased expression of AKR1B1 protein; Copper results in decreased expression of AKR1B1 mRNAPMID:18993053 PMID:30556269
Akr1b1increases expressionISOAkr1b1 (Rattus norvegicus)6480464CTDCopper results in increased expression of AKR1B1 mRNAPMID:22465980
Akr1b1multiple interactionsISOAKR1B1 (Homo sapiens)6480464CTD[Chelating Agents binds to Copper] which results in increased expression of AKR1B1 mRNA; [NSC 689534 binds to Copper] which results in increased expression of AKR1B1 mRNAPMID:20971185 PMID:30911355
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