GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MAPT | increases phosphorylation | EXP | | 6480464 | CTD | Copper results in increased phosphorylation of MAPT protein | PMID:25671100 | MAPT | multiple interactions | EXP | | 6480464 | CTD | [Copper binds to Thiosemicarbazones analog] which results in decreased phosphorylation of MAPT protein; [Zinc Acetate results in decreased abundance of Copper] which results in decreased phosphorylation of MAPT protein; tetrathiomolybdate inhibits the reaction [Copper results in increased phosphorylation of MAPT protein] | PMID:19122148 PMID:25671100 | MAPT | decreases expression | ISO | Mapt (Rattus norvegicus) | 6480464 | CTD | Copper results in decreased expression of MAPT mRNA | PMID:22465980 | MAPT | multiple interactions | ISO | Mapt (Mus musculus) | 6480464 | CTD | Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX1 protein]; Copper promotes the reaction [[PSEN1 gene mutant form co-treated with APP gene mutant form co-treated with MAPT gene mutant form] results in decreased expression of CPLX2 protein] | PMID:25352456 | | ||||||||||||||||||||||
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