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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:104736480464CTDCopper results in decreased expression of NQO1 mRNA

PMID:16243960
increases activityISORGD:104736480464CTDCopper results in increased activity of NQO1 protein

PMID:16243960
increases activityISORGD:25036480464CTDCopper results in increased activity of NQO1 promoter

PMID:14576086
increases expressionISORGD:104736480464CTDCopper results in increased expression of NQO1 mRNA, Copper results in increased expression of NQO1 protein

PMID:18752316
increases expressionISORGD:25036480464CTDCopper results in increased expression of NQO1 mRNA

PMID:22465980
multiple interactionsISORGD:104736480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide promotes the reaction [Copper results in decreased expression of NQO1 mRNA]], Buthionine Sulfoximine promotes the reaction [Copper results in increased expression of NQO1 mRNA], Buthionine Sulfoximine promotes the reaction [Copper results in increased expression of NQO1 protein], Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein], Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA], Cycloheximide promotes the reaction [Copper results in decreased expression of NQO1 mRNA], pyrazolanthrone inhibits the reaction [Copper results in increased expression of NQO1 mRNA], pyrazolanthrone inhibits the reaction [Copper results in increased expression of NQO1 protein], SB 203580 promotes the reaction [Copper results in increased expression of NQO1 mRNA], Tetradecanoylphorbol Acetate inhibits the reaction [Copper results in increased expression of NQO1 mRNA], Tetradecanoylphorbol Acetate inhibits the reaction [Copper results in increased expression of NQO1 protein], U 0126 promotes the reaction [Copper results in increased expression of NQO1 mRNA]

PMID:16243960, PMID:18752316
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.