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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620160
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bid
Name: BH3 interacting domain death agonist
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bidincreases expressionEXP 6480464CTDCopper results in increased expression of BID protein modified formPMID:30556269
Bidincreases cleavageISOBid (Mus musculus)6480464CTDCopper analog results in increased cleavage of BID proteinPMID:22000994
Bidmultiple interactionsISOBID (Homo sapiens)6480464CTD[Chelating Agents binds to Copper] which results in increased expression of BID mRNA; [Copper co-treated with di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone] results in increased cleavage of BID protein; [NSC 689534 binds to Copper] which results in decreased expression of BID mRNAPMID:20971185 PMID:21750178 PMID:30911355
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