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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpc1
Name: glypican 1
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCopper results in increased expression of GPC1 mRNA

PMID:30556269
affects bindingISORGD:621456480464CTDGPC1 protein binds to Copper

PMID:12732622
increases oxidationISORGD:621456480464CTDGPC1 protein results in increased oxidation of Copper

PMID:12732622
increases reductionISORGD:621456480464CTDGPC1 protein modified form results in increased reduction of Copper

PMID:12732622
multiple interactionsISORGD:621456480464CTD[APLP2 protein co-treated with Copper] results in decreased degradation of GPC1 protein modified form, [APP protein co-treated with Copper] results in decreased degradation of GPC1 protein modified form, [APP protein co-treated with Copper] results in increased degradation of GPC1 protein modified form, Copper affects the localization of [GPC1 protein co-treated with PRNP protein], PRNP protein affects the reaction [Copper results in increased nitrosation of GPC1 protein]

PMID:15677459, PMID:16923158, PMID:18717736
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.