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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ins2
Name: insulin 2
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins2affects transportISOINS (Homo sapiens)6480464CTDINS protein affects the transport of CopperPMID:17109627
Ins2multiple interactionsISOINS (Homo sapiens)6480464CTD[Copper co-treated with Ascorbic Acid] results in increased oxidation of and affects the folding of INS protein; INS protein inhibits the reaction [ATP7B protein affects the export of Copper]; Trientine inhibits the reaction [[Copper co-treated with Ascorbic Acid] results in increased oxidation of and affects the folding of INS protein]PMID:17109627 PMID:23403016
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