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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2189
Species: Rattus norvegicus
RGD Object: Gene
Symbol: B2m
Name: beta-2 microglobulin
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
B2mmultiple interactionsISOB2m (Mus musculus)6480464CTD[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of B2M mRNA; MT1 affects the reaction [Copper results in increased expression of B2M mRNA]; MT2 affects the reaction [Copper results in increased expression of B2M mRNA]PMID:15467011 PMID:16629173
B2mmultiple interactionsISOB2M (Homo sapiens)6480464CTDCopper binds to and results in decreased folding of and results in decreased stability of B2M protein; Copper promotes the reaction [B2M protein binds to B2M protein]; Urea promotes the reaction [Copper promotes the reaction [B2M protein binds to B2M protein]]PMID:16513784 PMID:17254602
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