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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733289
Species: Homo sapiens
RGD Object: Gene
Symbol: RACK1
Name: receptor for activated C kinase 1
Acc ID: CHEBI:28689
Term: dehydroepiandrosterone
Definition: An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Chemical ID: MESH:D003687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RACK1increases expressionEXP 6480464CTDDehydroepiandrosterone results in increased expression of RACK1 mRNA; Dehydroepiandrosterone results in increased expression of RACK1 proteinPMID:27239218 PMID:28412309
RACK1multiple interactionsEXP 6480464CTDAR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; AR protein affects the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 mRNA]; Flutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of RACK1 protein]PMID:27239218 PMID:28412309
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