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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737488
Species: Mus musculus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:28683
Term: kynurenine
Definition: A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Chemical ID: MESH:D007737
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngincreases chemical synthesisISOIFNG (Homo sapiens)6480464CTDIFNG protein results in increased chemical synthesis of KynureninePMID:32822738
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[IFNG protein co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased abundance of Kynurenine]; [IFNG protein co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased abundance of Kynurenine; salinomycin inhibits the reaction [IFNG protein results in increased chemical synthesis of Kynurenine]PMID:32781018 PMID:32822738
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