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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735760
Species: Homo sapiens
RGD Object: Gene
Symbol: ATF3
Name: activating transcription factor 3
Acc ID: CHEBI:28619
Term: acrylamide
Definition: A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia.
Chemical ID: MESH:D020106
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATF3increases expressionEXP 6480464CTDAcrylamide results in increased expression of ATF3 mRNAPMID:32763439
ATF3decreases expressionISOAtf3 (Rattus norvegicus)6480464CTDAcrylamide results in decreased expression of ATF3 mRNAPMID:28959563
ATF3increases expressionISOAtf3 (Mus musculus)6480464CTDAcrylamide results in increased expression of ATF3 mRNAPMID:25531190 PMID:35032568
ATF3multiple interactionsISOAtf3 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Acrylamide results in increased expression of and affects the localization of ATF3 protein]; Acrylamide results in increased expression of and affects the localization of ATF3 protein; ATF3 protein promotes the reaction [Acrylamide results in increased expression of CDKN1A protein]; ATF3 protein promotes the reaction [Acrylamide results in increased expression of TRP53 protein]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of ATF3 protein]; SB 203580 inhibits the reaction [Acrylamide results in increased expression of ATF3 protein]PMID:25531190
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