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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619551
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS1
Name: nitric oxide synthase 1
Acc ID: CHEBI:28619
Term: acrylamide
Definition: A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia.
Chemical ID: MESH:D020106
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS1decreases expressionISONos1 (Rattus norvegicus)6480464CTDAcrylamide results in decreased expression of NOS1 mRNA; Acrylamide results in decreased expression of NOS1 proteinPMID:15977197 PMID:28959563
NOS1increases expressionISONos1 (Mus musculus)6480464CTDAcrylamide results in increased expression of NOS1 mRNAPMID:34896238
NOS1multiple interactionsISONos1 (Mus musculus)6480464CTDAcrylamide inhibits the reaction [Streptozocin results in increased expression of NOS1 mRNA]PMID:34896238
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