GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | decreases expression | EXP | | 6480464 | CTD | Acrylamide results in decreased expression of IL1B mRNA | PMID:28959563 | Il1b | increases expression | EXP | | 6480464 | CTD | Acrylamide results in increased expression of IL1B mRNA; Acrylamide results in increased expression of IL1B protein | PMID:25858877 PMID:25934431 PMID:29913234 PMID:31073625 PMID:36598108 | Il1b | multiple interactions | EXP | | 6480464 | CTD | [Acrylamide co-treated with Aluminum Chloride] results in increased expression of IL1B mRNA; [Aluminum Chloride co-treated with Acrylamide] results in increased expression of IL1B mRNA; boric acid inhibits the reaction [Acrylamide results in increased expression of IL1B mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of IL1B protein] | PMID:25858877 PMID:25934431 PMID:29913234 PMID:36598108 | Il1b | decreases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | Acrylamide analog results in decreased expression of IL1B mRNA; Acrylamide analog results in decreased expression of IL1B protein | PMID:18287786 | Il1b | increases expression | ISO | Il1b (Mus musculus) | 6480464 | CTD | Acrylamide results in increased expression of IL1B mRNA; Acrylamide results in increased expression of IL1B protein; Acrylamide results in increased expression of IL1B protein modified form | PMID:27836571 PMID:31073625 PMID:32014472 PMID:34896238 PMID:37037409 | Il1b | increases response to substance | ISO | Il1b (Mus musculus) | 6480464 | CTD | IL1B gene mutant form results in increased susceptibility to Acrylamide | PMID:37540211 | Il1b | increases secretion | ISO | Il1b (Mus musculus) | 6480464 | CTD | Acrylamide results in increased secretion of IL1B protein | PMID:27836571 PMID:28526328 PMID:37037409 | Il1b | multiple interactions | ISO | Il1b (Mus musculus) | 6480464 | CTD | [NFE2L2 protein affects the susceptibility to Acrylamide] which affects the expression of IL1B mRNA; Acrylamide inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Acrylamide results in increased secretion of IL1B protein]; IL1B gene mutant form inhibits the reaction [Acrylamide results in increased expression of GCLC mRNA]; IL1B gene mutant form inhibits the reaction [Acrylamide results in increased expression of GPX1 mRNA]; IL1B gene mutant form inhibits the reaction [Acrylamide results in increased expression of GPX4 mRNA]; LRRK2 promotes the reaction [Acrylamide results in increased secretion of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Acrylamide results in increased expression of IL1B protein modified form]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [Acrylamide results in increased expression of IL1B protein]; NLRP3 gene mutant form inhibits the reaction [Acrylamide results in increased expression of IL1B protein modified form]; NLRP3 gene mutant form inhibits the reaction [Acrylamide results in increased expression of IL1B protein]; NLRP3 protein promotes the reaction [Acrylamide results in increased expression of IL1B protein modified form]; NLRP3 protein promotes the reaction [Acrylamide results in increased expression of IL1B protein] | PMID:31073625 PMID:32014472 PMID:33872730 PMID:34896238 PMID:37037409 PMID:37540211 | | ||||||||||||||||||||||
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