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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:28619
Term: acrylamide
Definition: A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia.
Chemical ID: MESH:D020106
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1increases cleavageEXP 6480464CTDAcrylamide results in increased cleavage of PARP1 proteinPMID:27634458
PARP1multiple interactionsEXP 6480464CTD4-phenylbutyric acid inhibits the reaction [Acrylamide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased cleavage of PARP1 protein]PMID:27634458
PARP1increases expressionISOParp1 (Mus musculus)6480464CTDAcrylamide results in increased expression of PARP1 proteinPMID:36565847
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