GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TNF | increases expression | ISO | Tnf (Mus musculus) | 6480464 | CTD | Acrylamide results in increased expression of TNF mRNA | PMID:27836571 PMID:28526328 PMID:34896238 PMID:37037409 | TNF | increases expression | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Acrylamide results in increased expression of TNF mRNA; Acrylamide results in increased expression of TNF protein | PMID:25858877 PMID:25934431 PMID:29426002 PMID:29913234 PMID:36598108 | TNF | increases secretion | ISO | Tnf (Mus musculus) | 6480464 | CTD | Acrylamide results in increased secretion of TNF protein | PMID:27836571 PMID:28526328 PMID:37037409 | TNF | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | [NFE2L2 protein affects the susceptibility to Acrylamide] which affects the expression of TNF mRNA; Acrylamide inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Acrylamide results in increased secretion of TNF protein]; TLR2 protein promotes the reaction [Acrylamide results in increased secretion of TNF protein] | PMID:33872730 PMID:34896238 PMID:37037409 | TNF | multiple interactions | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Acrylamide results in increased expression of TNF mRNA]; [Acrylamide co-treated with Aluminum Chloride] results in increased expression of TNF mRNA; [Aluminum Chloride co-treated with Acrylamide] results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of TNF protein]; boric acid inhibits the reaction [Acrylamide results in increased expression of TNF mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [Acrylamide results in increased expression of TNF mRNA]; U 0126 inhibits the reaction [Acrylamide results in increased expression of TNF mRNA] | PMID:25858877 PMID:25934431 PMID:29426002 PMID:29913234 PMID:36598108 | | ||||||||||||||||||||||
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