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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:28600
Term: farnesol
Definition: A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.
Chemical ID: MESH:D005204
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1decreases expressionEXP 6480464CTDFarnesol analog results in decreased expression of CYP2E1 mRNA; Farnesol results in decreased expression of CYP2E1 mRNAPMID:30611723
CYP2E1multiple interactionsEXP 6480464CTD[Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2E1 mRNA; Farnesol analog inhibits the reaction [Oleic Acid results in increased expression of CYP2E1 mRNA]PMID:30611723
CYP2E1increases activityISOCyp2e1 (Rattus norvegicus)6480464CTDFarnesol results in increased activity of CYP2E1 proteinPMID:15840382
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