GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2d22 | decreases activity | EXP | | 6480464 | CTD | Quinidine results in decreased activity of CYP2D6 protein | PMID:18420780 | Cyp2d22 | decreases activity | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | Quinidine results in decreased activity of CYP2D6 gene mutant form; Quinidine results in decreased activity of CYP2D6 protein | PMID:11673748 PMID:12464242 PMID:12467917 PMID:12814958 PMID:15155557 PMID:15306208 PMID:15860655 PMID:16035375 PMID:19328226 PMID:21336516 PMID:21915887 PMID:23850985 PMID:24167220 PMID:26599973 PMID:28119166 PMID:33253783 PMID:33438235 PMID:8819299 | Cyp2d22 | increases metabolic processing | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | CYP2D6 protein results in increased metabolism of Quinidine | PMID:17702393 | Cyp2d22 | multiple interactions | ISO | Cyp2d4 (Rattus norvegicus) | 6480464 | CTD | [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride | PMID:20669986 | Cyp2d22 | multiple interactions | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | [Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 4-hydroxy-N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Quinidine affects the reaction [CYP2D6 protein polymorphism affects the metabolism of dacomitinib]; Quinidine binds to and results in decreased activity of CYP2D6 protein; Quinidine inhibits the reaction [3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin results in increased metabolism of CYP2D6 protein]; Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins]; Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine]; Quinidine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Atomoxetine Hydrochloride]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein] | PMID:11377097 PMID:11560869 PMID:12569440 PMID:14652237 PMID:16595712 PMID:18238857 PMID:19230594 PMID:20345925 PMID:20590588 PMID:21277363 PMID:21915887 PMID:23850985 PMID:26599973 PMID:28119166 PMID:28887089 PMID:31515991 PMID:32198085 PMID:34431675 PMID:34936353 | | ||||||||||||||||||||||
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