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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:28593
Term: quinidine
Definition: A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.
Chemical ID: MESH:D011802
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride

PMID:20669986
decreases activityISORGD:7362176480464CTDQuinidine results in decreased activity of CYP2D6 gene mutant form, Quinidine results in decreased activity of CYP2D6 protein

PMID:11673748, PMID:12464242, PMID:12467917, PMID:12814958, PMID:15155557, PMID:15306208, PMID:15860655, PMID:16035375, PMID:19328226, PMID:21336516, PMID:21915887, PMID:23850985, PMID:24167220, PMID:26599973, PMID:28119166, PMID:8819299
decreases activityISORGD:7362186480464CTDQuinidine results in decreased activity of CYP2D6 protein

PMID:18420780
increases metabolic processingISORGD:7362176480464CTDCYP2D6 protein results in increased metabolism of Quinidine

PMID:17702393
multiple interactionsISORGD:7362176480464CTD[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone, [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine, [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 4-hydroxy-N-desmethyltamoxifen, [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite, [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen, [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan, Quinidine binds to and results in decreased activity of CYP2D6 protein, Quinidine inhibits the reaction [3-(2-(N, N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin results in increased metabolism of CYP2D6 protein], Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins], Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine], Quinidine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan], Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol], Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol], Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan], Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod], Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]

PMID:11377097, PMID:11560869, PMID:12569440, PMID:14652237, PMID:16595712, PMID:18238857, PMID:19230594, PMID:20345925, PMID:20590588, PMID:21277363, PMID:21915887, PMID:23850985, PMID:26599973, PMID:28119166, PMID:28887089
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.