Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Txnrd1
Name: thioredoxin reductase 1
Acc ID: CHEBI:28553
Term: selenocystine
Definition: A diselenide that has formula C6H12N2O4Se2.
Chemical ID: MESH:C009226
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txnrd1decreases response to substanceISOTXNRD1 (Homo sapiens)6480464CTDTXNRD1 protein results in decreased susceptibility to selenocystinePMID:20920480
Txnrd1increases expressionISOTXNRD1 (Homo sapiens)6480464CTDselenocystine results in increased expression of TXNRD1 mRNA; selenocystine results in increased expression of TXNRD1 proteinPMID:22807314
Txnrd1multiple interactionsISOTXNRD1 (Homo sapiens)6480464CTDNFE2L2 mutant form inhibits the reaction [selenocystine results in increased expression of TXNRD1 mRNA]PMID:22807314
Go Back to source page   Continue to Ontology report