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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:28544
Term: digitoxin
Definition: A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.
Chemical ID: MESH:D004074
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases cleavageISOCASP8 (Homo sapiens)6480464CTDDigitoxin analog results in increased cleavage of CASP8 protein; Digitoxin results in increased cleavage of CASP8 proteinPMID:22037315 PMID:34717917
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTDDigitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]; Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]; HIF1A protein affects the reaction [Digitoxin affects the reaction [STAT3 protein affects the cleavage of CASP8 protein]]; STAT3 protein affects the reaction [Digitoxin affects the reaction [HIF1A protein affects the cleavage of CASP8 protein]]PMID:34717917
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