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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:28544
Term: digitoxin
Definition: A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.
Chemical ID: MESH:D004074
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsISORGD:7309816480464CTD2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]] 2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]] Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein] Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein] Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein] Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein] Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]

PMID:19446813
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