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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mgmt
Name: O-6-methylguanine-DNA methyltransferase
Acc ID: CHEBI:28534
Term: 1,2-dibromoethane
Definition: A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae.
Chemical ID: MESH:D015946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mgmtaffects bindingISOMGMT (Homo sapiens)6480464CTDEthylene Dibromide binds to MGMT proteinPMID:17226938
Mgmtincreases response to substanceISOMGMT (Homo sapiens)6480464CTDMGMT protein results in increased susceptibility to Ethylene DibromidePMID:17226938
Mgmtmultiple interactionsISOMGMT (Homo sapiens)6480464CTDEthylene Dibromide binds to and results in decreased activity of MGMT protein; MGMT protein affects the metabolism of and results in increased activity of Ethylene Dibromide; MGMT protein results in increased activity of and results in increased susceptibility to Ethylene DibromidePMID:10894884 PMID:12151404 PMID:14645247
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