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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:28527
Term: rutin
Definition: A rutinoside that is quercetin with the hydroxy group at position C-3 substituted with glucose and rhamnose sugar groups.
Chemical ID: MESH:D012431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDRutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX protein]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]PMID:32881150 PMID:33413359
Baxaffects expressionISOBAX (Homo sapiens)6480464CTDRutin affects the expression of BAX proteinPMID:15975156
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDRutin results in increased expression of BAX proteinPMID:28811126
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDRutin inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]PMID:29522708
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