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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:28509
Term: chloroethene
Definition: A monohaloethene that is ethene in which one of the hydrogens has been replaced by a chloro group.
Chemical ID: MESH:D014752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1affects metabolic processingEXP 6480464CTDCYP2E1 protein affects the metabolism of Vinyl ChloridePMID:17710613
CYP2E1affects response to substanceEXP 6480464CTDCYP2E1 gene polymorphism affects the susceptibility to Vinyl ChloridePMID:20134343
CYP2E1increases activityEXP 6480464CTDVinyl Chloride results in increased activity of CYP2E1 proteinPMID:17710613
CYP2E1increases metabolic processingEXP 6480464CTDCYP2E1 protein results in increased metabolism of Vinyl ChloridePMID:18350910
CYP2E1increases oxidationEXP 6480464CTDCYP2E1 protein results in increased oxidation of Vinyl ChloridePMID:1664256
CYP2E1increases response to substanceEXP 6480464CTDCYP2E1 gene polymorphism results in increased susceptibility to Vinyl Chloride; CYP2E1 gene SNP results in increased susceptibility to Vinyl ChloridePMID:16270392 PMID:18420361 PMID:20100738
CYP2E1multiple interactionsEXP 6480464CTDCYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of KRAS gene]; CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]; CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of KRAS gene]; CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of TP53 gene]PMID:12010862 PMID:12705718 PMID:17384900
CYP2E1affects metabolic processingISOCyp2e1 (Rattus norvegicus)6480464CTDCYP2E1 protein affects the metabolism of Vinyl ChloridePMID:17710613 PMID:7871537
CYP2E1increases activityISOCyp2e1 (Rattus norvegicus)6480464CTDVinyl Chloride results in increased activity of CYP2E1 proteinPMID:15211785 PMID:17710613
CYP2E1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTD1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Vinyl Chloride]PMID:7871537
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