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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737121
Species: Mus musculus
RGD Object: Gene
Symbol: Ccn5
Name: cellular communication network factor 5
Acc ID: CHEBI:28499
Term: kaempferol
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Chemical ID: MESH:C006552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13514966480464CTDkaempferol results in increased expression of CCN5 mRNA

PMID:23384675
multiple interactionsISORGD:13514966480464CTDESR1 protein inhibits the reaction [kaempferol results in increased expression of CCN5 mRNA]

PMID:23384675
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.