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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1618016
Species: Mus musculus
RGD Object: Gene
Symbol: Greb1
Name: gene regulated by estrogen in breast cancer protein
Acc ID: CHEBI:28499
Term: kaempferol
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Chemical ID: MESH:C006552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Greb1increases expressionISOGREB1 (Homo sapiens)6480464CTDkaempferol results in increased expression of GREB1 mRNAPMID:20846786 PMID:33405908 PMID:35307500
Greb1multiple interactionsISOGREB1 (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [kaempferol results in increased expression of GREB1 mRNA]; kaempferol promotes the reaction [ESR1 protein binds to GREB1 enhancer]; kaempferol promotes the reaction [NCOA3 protein binds to GREB1 enhancer]PMID:20846786 PMID:33405908
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