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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11092
Species: Mus musculus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:28499
Term: kaempferol
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment.
Chemical ID: MESH:C006552
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgraffects bindingISOPGR (Homo sapiens)6480464CTDkaempferol binds to PGR proteinPMID:14579009
Pgrincreases expressionISOPGR (Homo sapiens)6480464CTDkaempferol results in increased expression of PGR mRNAPMID:23384675 PMID:35307500
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTDESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA]; kaempferol inhibits the reaction [Progesterone binds to PGR protein]PMID:14579009 PMID:23384675
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