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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731002
Species: Homo sapiens
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: CHEBI:28498
Term: acadesine
Definition: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.
Chemical ID: MESH:C011651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3multiple interactionsEXP 6480464CTDacadesine promotes the reaction [Isoniazid results in increased cleavage of CASP3 protein]PMID:28556920
CASP3increases cleavageISOCasp3 (Mus musculus)6480464CTDacadesine results in increased cleavage of CASP3 proteinPMID:22137261 PMID:25603053
CASP3multiple interactionsISOCasp3 (Rattus norvegicus)6480464CTDacadesine inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]PMID:26989860
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