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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730836
Species: Homo sapiens
RGD Object: Gene
Symbol: CHGA
Name: chromogranin A
Acc ID: CHEBI:28487
Term: reserpine
Definition: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Chemical ID: MESH:D012110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CHGAincreases activityISOChga (Mus musculus)6480464CTDReserpine results in increased activity of CHGA promoterPMID:12799369
CHGAincreases expressionISOChga (Rattus norvegicus)6480464CTDReserpine results in increased expression of CHGA mRNAPMID:1907749 PMID:8189248
CHGAmultiple interactionsISOChga (Mus musculus)6480464CTDCHGA protein alternative form inhibits the reaction [Reserpine results in increased activity of CHGA promoter]; Chlorisondamine inhibits the reaction [Reserpine results in increased activity of CHGA promoter]PMID:12799369
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