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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10711
Species: Mus musculus
RGD Object: Gene
Symbol: Hmgb1
Name: high mobility group box 1
Acc ID: CHEBI:28445
Term: vincristine
Definition: A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.
Chemical ID: MESH:D014750
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgb1decreases expressionISOHmgb1 (Rattus norvegicus)6480464CTDVincristine results in decreased expression of HMGB1 proteinPMID:27474498
Hmgb1decreases response to substanceISOHMGB1 (Homo sapiens)6480464CTDHMGB1 protein results in decreased susceptibility to VincristinePMID:27807322
Hmgb1increases secretionISOHMGB1 (Homo sapiens)6480464CTDVincristine results in increased secretion of HMGB1 proteinPMID:27807322
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