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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550689
Species: Mus musculus
RGD Object: Gene
Symbol: Fut8
Name: fucosyltransferase 8
Acc ID: CHEBI:28420
Term: p-chloromercuribenzoic acid
Definition: A mercuribenzoic acid that has formula C7H5ClHgO2.
Chemical ID: MESH:D020245
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fut8decreases activityISOFUT8 (Homo sapiens)6480464CTDp-Chloromercuribenzoic Acid results in decreased activity of FUT8 proteinPMID:12770769
Fut8decreases expressionISOFUT8 (Homo sapiens)6480464CTDp-Chloromercuribenzoic Acid results in decreased expression of FUT8 mRNAPMID:26272509
Fut8multiple interactionsISOFUT8 (Homo sapiens)6480464CTD[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FUT8 mRNA; Fucose analog inhibits the reaction [p-Chloromercuribenzoic Acid results in decreased activity of FUT8 protein]; Guanosine Diphosphate inhibits the reaction [p-Chloromercuribenzoic Acid results in decreased activity of FUT8 protein]PMID:12770769 PMID:27188386
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