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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735902
Species: Mus musculus
RGD Object: Gene
Symbol: Acan
Name: aggrecan
Acc ID: CHEBI:28393
Term: beta-D-glucosamine
Definition: A 2-amino-2-deoxy-D-glucopyranose that is D-glucosamine having a beta-configuration at the anomeric position.
Chemical ID: MESH:D005944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acanincreases expressionEXP 6480464CTDGlucosamine results in increased expression of ACAN mRNAPMID:16872674
Acanaffects expressionISOACAN (Homo sapiens)6480464CTDGlucosamine analog affects the expression of ACAN mRNAPMID:17337215
Acandecreases expressionISOACAN (Homo sapiens)6480464CTDGlucosamine analog results in decreased expression of ACAN mRNAPMID:16300972
Acanincreases expressionISOACAN (Homo sapiens)6480464CTDGlucosamine analog results in increased expression of ACAN protein; Glucosamine results in increased expression of ACAN mRNA; Glucosamine results in increased expression of ACAN proteinPMID:12801482 PMID:17337215 PMID:18321735
Acanmultiple interactionsISOAcan (Rattus norvegicus)6480464CTDGlucosamine inhibits the reaction [IL1B results in decreased expression of ACAN mRNA]PMID:17109745
Acanmultiple interactionsISOACAN (Homo sapiens)6480464CTDGlucosamine analog affects the reaction [IL1B results in decreased expression of ACAN mRNA]; Glucosamine inhibits the reaction [IL1B protein results in decreased expression of ACAN mRNA]; Glucosamine results in decreased cleavage of and results in decreased secretion of ACAN proteinPMID:17337215 PMID:18321735 PMID:19909832
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