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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp3
Name: matrix metallopeptidase 3
Acc ID: CHEBI:28393
Term: beta-D-glucosamine
Definition: A 2-amino-2-deoxy-D-glucopyranose that is D-glucosamine having a beta-configuration at the anomeric position.
Chemical ID: MESH:D005944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp3increases expressionEXP 6480464CTDGlucosamine results in increased expression of MMP3 mRNAPMID:17109745
Mmp3multiple interactionsEXP 6480464CTDGlucosamine inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]; IL1B promotes the reaction [Glucosamine results in increased expression of MMP3 mRNA]PMID:11229466 PMID:17109745
Mmp3decreases expressionISOMMP3 (Homo sapiens)6480464CTDGlucosamine analog results in decreased expression of MMP3 mRNAPMID:16300972
Mmp3multiple interactionsISOMMP3 (Homo sapiens)6480464CTD[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA; [Glucosamine co-treated with Chondroitin Sulfates] results in decreased secretion of MMP3 protein; Glucosamine analog inhibits the reaction [IL1B protein results in increased expression of MMP3]; Glucosamine analog inhibits the reaction [IL1B results in increased expression of and results in increased secretion of MMP3 protein]; Glucosamine analog inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]; Glucosamine inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Glucosamine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]; Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]; Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 protein]; Glucosamine results in decreased expression of and results in decreased activity of MMP3 proteinPMID:12801482 PMID:15144122 PMID:17925024 PMID:18080321 PMID:18340449 PMID:20110869
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