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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:28304
Term: heparin
Definition: A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.
Chemical ID: MESH:D006493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6multiple interactionsEXP 6480464CTDHeparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA]PMID:16401727
Il6increases expressionISOIL6 (Homo sapiens)6480464CTDHeparin results in increased expression of IL6 proteinPMID:16391376
Il6increases secretionISOIL6 (Homo sapiens)6480464CTDHeparin analog results in increased secretion of IL6 proteinPMID:26476401
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTDHeparin inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]PMID:25633564
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