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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2609
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf2
Name: fibroblast growth factor 2
Acc ID: CHEBI:28304
Term: heparin
Definition: A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.
Chemical ID: MESH:D006493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf2affects activityEXP 6480464CTDHeparin affects the activity of FGF2 proteinPMID:15232299
Fgf2affects bindingEXP 6480464CTD[Heparin binds to FGFR2 protein alternative form] which binds to FGF2 proteinPMID:10860838
Fgf2decreases expressionEXP 6480464CTDHeparin results in decreased expression of FGF2 proteinPMID:8441232
Fgf2multiple interactionsEXP 6480464CTDHeparin affects the reaction [FGF2 protein binds to FGFR4 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAP2K2 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; Heparin inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]PMID:10336501 PMID:14966081
Fgf2affects bindingISOFGF2 (Homo sapiens)6480464CTDHeparin binds to FGF2 protein; Heparin binds to FGFR1 protein binds to FGF2 proteinPMID:15096041 PMID:17524524
Fgf2multiple interactionsISOFgf2 (Mus musculus)6480464CTDHeparin promotes the reaction [FGFR1 protein binds to FGF2 protein]; Heparin promotes the reaction [FGFR2 protein binds to FGF2 protein]PMID:1373495 PMID:1379594
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