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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308999
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cldn9
Name: claudin 9
Acc ID: CHEBI:28262
Term: dimethyl sulfoxide
Definition: A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Chemical ID: MESH:D004121
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cldn9decreases methylationISORGD:13190966480464CTDDimethyl Sulfoxide results in decreased methylation of CLDN9 promoter

PMID:18661270
Cldn9increases expressionISORGD:13190966480464CTDDimethyl Sulfoxide results in increased expression of CLDN9 mRNA

PMID:18661270
Cldn9multiple interactionsISORGD:13190966480464CTDDimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN9 mRNA]

PMID:18661270
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.