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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730981
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1B
Name: interleukin 1 beta
Acc ID: CHEBI:28260
Term: galactose
Definition: An aldohexose that is the C-4 epimer of glucose.
Chemical ID: MESH:D005690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1Bincreases expressionISOIl1b (Mus musculus)6480464CTDGalactose results in increased expression of IL1B mRNA; Galactose results in increased expression of IL1B proteinPMID:23612000 PMID:28974442 PMID:33761044
IL1Bincreases expressionISOIl1b (Rattus norvegicus)6480464CTDGalactose results in increased expression of IL1B proteinPMID:32295448
IL1Bincreases secretionISOIl1b (Mus musculus)6480464CTDGalactose results in increased secretion of IL1B proteinPMID:22687555
IL1Bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein; albicanol inhibits the reaction [Galactose results in increased expression of IL1B mRNA]; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; catalpol inhibits the reaction [Galactose results in increased expression of IL1B protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]; Lycopene inhibits the reaction [Galactose results in increased expression of IL1B protein]; protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL1B protein]PMID:22687555 PMID:23612000 PMID:28974442 PMID:33761044 PMID:35537655
IL1Bmultiple interactionsISOIl1b (Rattus norvegicus)6480464CTD[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein; thymoquinone inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL1B protein]PMID:29405769
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