GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | increases secretion | EXP | | 6480464 | CTD | Galactose results in increased secretion of IL6 protein | PMID:22687555 | Il6 | multiple interactions | EXP | | 6480464 | CTD | [Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein; [Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL6 protein; [Lipopolysaccharides co-treated with Galactose] results in increased expression of IL6 protein; astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein]; Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in increased expression of IL6 protein]; protocatechuic acid inhibits the reaction [Galactose results in increased secretion of IL6 protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of IL6 protein]; scoparone inhibits the reaction [[Galactose co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL6 protein] | PMID:22687555 PMID:23535186 PMID:34416243 PMID:35537655 | Il6 | increases expression | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | Galactose results in increased expression of IL6 mRNA; Galactose results in increased expression of IL6 protein | PMID:32295448 PMID:35259467 | Il6 | increases secretion | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Galactose results in increased secretion of IL6 protein | PMID:29412148 | Il6 | multiple interactions | ISO | IL6 (Homo sapiens) | 6480464 | CTD | 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside F1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside M1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside Rg3 inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside Rh1 inhibits the reaction [Galactose results in increased secretion of IL6 protein]; ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein] | PMID:29412148 | Il6 | multiple interactions | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | Galactose promotes the reaction [sodium arsenite results in increased expression of IL6 mRNA] | PMID:35259467 | | ||||||||||||||||||||||
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