Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	733128
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	VIM
Name:	vimentin

Acc ID:	CHEBI:2825
Term:	aristolochic acid A
Definition:	An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Chemical ID:	MESH:C000228

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
VIM	decreases expression	EXP		6480464	CTD	aristolochic acid I results in decreased expression of VIM mRNA	PMID:33212167
VIM	increases expression	EXP		6480464	CTD	aristolochic acid I results in increased expression of VIM protein	PMID:32898628
VIM	multiple interactions	EXP		6480464	CTD	[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of VIM protein; BMP7 protein inhibits the reaction [[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of VIM protein]; BMP7 protein promotes the reaction [[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of VIM protein]	PMID:25663515
VIM	increases expression	ISO	Vim (Mus musculus)	6480464	CTD	aristolochic acid I results in increased expression of VIM protein	PMID:32898628
VIM	multiple interactions	ISO	Vim (Rattus norvegicus)	6480464	CTD	[aristolochic acid I co-treated with aristolochic acid II] results in decreased expression of VIM mRNA; [aristolochic acid I co-treated with aristolochic acid II] results in increased expression of VIM protein	PMID:23912714 PMID:25663515
VIM	multiple interactions	ISO	Vim (Mus musculus)	6480464	CTD	SB 290157 inhibits the reaction [aristolochic acid I results in increased expression of VIM protein]	PMID:32898628

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