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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:2825
Term: aristolochic acid A
Definition: An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Chemical ID: MESH:C000228
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDaristolochic acid I results in increased expression of BAX mRNA; aristolochic acid I results in increased expression of BAX proteinPMID:34167444 PMID:35850572 PMID:36037877
Baxmultiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [aristolochic acid I results in increased expression of BAX mRNA]; Grape Seed Proanthocyanidins inhibits the reaction [aristolochic acid I results in decreased expression of BAX protein]; Grape Seed Proanthocyanidins inhibits the reaction [aristolochic acid I results in increased expression of BAX mRNA]PMID:35850572 PMID:36037877
Baxincreases expressionISOBax (Mus musculus)6480464CTDaristolochic acid I results in increased expression of BAX proteinPMID:26656393 PMID:37084829
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDaristolochic acid I results in increased expression of BAX proteinPMID:31048001
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