GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GREM1 | decreases expression | EXP | | 6480464 | CTD | aristolochic acid I results in decreased expression of GREM1 mRNA | PMID:33212167 | GREM1 | increases expression | EXP | | 6480464 | CTD | aristolochic acid I results in increased expression of GREM1 mRNA; aristolochic acid I results in increased expression of GREM1 protein | PMID:22525892 | GREM1 | multiple interactions | EXP | | 6480464 | CTD | GREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased activity of BMP7 protein]; GREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of CDH1 protein]; GREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD1 protein modified form]; GREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD5 protein modified form]; GREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD9 protein modified form]; GREM1 mutant form inhibits the reaction [aristolochic acid I results in increased expression of ACTA2 protein]; GREM1 protein inhibits the reaction [BMP7 protein results in decreased susceptibility to aristolochic acid I] | PMID:22525892 | |
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