Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346462
Species: Homo sapiens
RGD Object: Gene
Symbol: GREM1
Name: gremlin 1, DAN family BMP antagonist
Acc ID: CHEBI:2825
Term: aristolochic acid A
Definition: An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Chemical ID: MESH:C000228
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GREM1decreases expressionEXP 6480464CTDaristolochic acid I results in decreased expression of GREM1 mRNAPMID:33212167
GREM1increases expressionEXP 6480464CTDaristolochic acid I results in increased expression of GREM1 mRNA; aristolochic acid I results in increased expression of GREM1 proteinPMID:22525892
GREM1multiple interactionsEXP 6480464CTDGREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased activity of BMP7 protein]; GREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of CDH1 protein]; GREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD1 protein modified form]; GREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD5 protein modified form]; GREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD9 protein modified form]; GREM1 mutant form inhibits the reaction [aristolochic acid I results in increased expression of ACTA2 protein]; GREM1 protein inhibits the reaction [BMP7 protein results in decreased susceptibility to aristolochic acid I]PMID:22525892
Go Back to source page   Continue to Ontology report