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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:28230
Term: hesperetin
Definition: A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.
Chemical ID: MESH:C013015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDhesperetin results in increased expression of NQO1 protein

PMID:31153982
multiple interactionsEXP 6480464CTD[Cisplatin co-treated with hesperetin] results in increased expression of NQO1 protein

PMID:31153982
multiple interactionsISORGD:104736480464CTDhesperetin inhibits the reaction [Cisplatin results in decreased expression of NQO1 protein]

PMID:31153982
multiple interactionsISORGD:25036480464CTDhesperetin inhibits the reaction [1, 2-Dimethylhydrazine results in decreased activity of NQO1 protein]

PMID:19497424
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.