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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313111
Species: Mus musculus
RGD Object: Gene
Symbol: Sirt6
Name: sirtuin 6
Acc ID: CHEBI:28230
Term: hesperetin
Definition: A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.
Chemical ID: MESH:C013015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt6increases expressionISOSIRT6 (Homo sapiens)6480464CTDhesperetin results in increased expression of SIRT6 proteinPMID:31153982
Sirt6multiple interactionsISOSIRT6 (Homo sapiens)6480464CTD[Cisplatin co-treated with hesperetin] results in increased expression of SIRT6 proteinPMID:31153982
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