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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10919
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc1
Name: ATP-binding cassette, sub-family C member 1
Acc ID: CHEBI:28230
Term: hesperetin
Definition: A trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position.
Chemical ID: MESH:C013015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1multiple interactionsISOABCC1 (Homo sapiens)6480464CTDhesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]PMID:16156793
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