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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NQO1increases expressionEXP 6480464CTDmethylmercuric chloride results in increased expression of NQO1 mRNAPMID:23179753 PMID:26272509 PMID:27188386 PMID:28001369
NQO1multiple interactionsEXP 6480464CTD[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NQO1 mRNAPMID:27188386
NQO1decreases expressionISONqo1 (Mus musculus)6480464CTDmethylmercuric chloride results in decreased expression of NQO1 mRNAPMID:23202902
NQO1increases expressionISONqo1 (Mus musculus)6480464CTDmethylmercuric chloride results in increased expression of NQO1 mRNAPMID:20061341
NQO1increases expressionISONqo1 (Rattus norvegicus)6480464CTDmethylmercuric chloride results in increased expression of NQO1 mRNAPMID:28736149
NQO1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTD[Hydrocarbons, Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in increased expression of NQO1 mRNA; [methylmercuric chloride affects the localization of NFE2L2 protein] which results in increased expression of NQO1 mRNAPMID:20421342 PMID:30744511
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