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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects localizationEXP 6480464CTDmethylmercuric chloride affects the localization of NFE2L2 proteinPMID:20402460
Nfe2l2decreases expressionEXP 6480464CTDmethylmercuric chloride results in decreased expression of NFE2L2 mRNAPMID:23202902 PMID:29850906
Nfe2l2affects localizationISONfe2l2 (Rattus norvegicus)6480464CTDmethylmercuric chloride affects the localization of NFE2L2 proteinPMID:20421342 PMID:28736149
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDmethylmercuric chloride affects the localization of NFE2L2 proteinPMID:24816296
Nfe2l2decreases response to substanceISONfe2l2 (Rattus norvegicus)6480464CTDNFE2L2 protein results in decreased susceptibility to methylmercuric chloridePMID:20421342
Nfe2l2increases expressionISONfe2l2 (Rattus norvegicus)6480464CTDmethylmercuric chloride results in increased expression of NFE2L2 mRNA; methylmercuric chloride results in increased expression of NFE2L2 proteinPMID:20421342 PMID:27298056 PMID:32061141 PMID:36813253
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDmethylmercuric chloride results in increased expression of NFE2L2 mRNA; methylmercuric chloride results in increased expression of NFE2L2 proteinPMID:23179753 PMID:27180086 PMID:27917510 PMID:28001369
Nfe2l2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTD[methylmercuric chloride affects the localization of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; [methylmercuric chloride affects the localization of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [methylmercuric chloride affects the localization of NFE2L2 protein] which results in increased expression of SLC7A11 mRNA; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]PMID:20421342 PMID:27298056 PMID:32061141 PMID:36813253
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Sodium Selenite affects the reaction [methylmercuric chloride affects the localization of NFE2L2 protein]PMID:24816296 PMID:27917510
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