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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases phosphorylationISOAkt1 (Mus musculus)6480464CTDmethylmercuric chloride results in decreased phosphorylation of AKT1 proteinPMID:33301842 PMID:33338554
AKT1increases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDmethylmercuric chloride results in increased phosphorylation of AKT1 proteinPMID:28736149
AKT1multiple interactionsISOAkt1 (Mus musculus)6480464CTDAKT1 protein mutant form inhibits the reaction [methylmercuric chloride results in increased cleavage of ATF6 protein]; AKT1 protein mutant form inhibits the reaction [methylmercuric chloride results in increased expression of ATF4 protein]; AKT1 protein mutant form inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein modified form]; AKT1 protein mutant form inhibits the reaction [methylmercuric chloride results in increased expression of CASP7 protein modified form]; AKT1 protein mutant form inhibits the reaction [methylmercuric chloride results in increased expression of ERN1 protein modified form]; AKT1 protein mutant form inhibits the reaction [methylmercuric chloride results in increased expression of PARP1 protein modified form]; AKT1 protein mutant form inhibits the reaction [methylmercuric chloride results in increased phosphorylation of EIF2AK3 protein]; AKT1 protein mutant form inhibits the reaction [methylmercuric chloride results in increased phosphorylation of EIF2S1 protein]; GHRL protein promotes the reaction [methylmercuric chloride results in decreased phosphorylation of AKT1 protein]PMID:31330229 PMID:33301842
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